Identify these significant daptomycin iv cubicin iv drug interactions with the rxlist drug interaction checker tool. The pharmacokinetics of daptomycin were evaluated in 12 healthy elderly subjects. It is a naturally occurring compound found in the soil saprotroph streptomyces roseosporus. If same iv line is used for sequential infusion of different drugs, flush line with a compatible infusion solution see compatibility under stability. Cubicin should be used only when prescribed during pregnancy. Another example of unexpected incompatibility is ketorolac tromethamine with several salts in which the organic drug is a cation e. The appropriate volume of the reconstituted solution concentration of 50 mgml should be further diluted into an iv infusion bag containing the specified volume of 0. Renal dose adjustment guidelines for antimicrobials crrt. The contents of a cubicin vial should be reconstituted, using aseptic. Tigecycline, colistin, daptomycin, vancomycin and teicoplanin.
Methods daptomycin vials were reconstituted with nacl 50 mgml. Gram positive infection an overview sciencedirect topics. It works by killing bacteria or preventing their growth. Antibiotic drugs, information, description on daptomycin. Physical and chemical potency analyses demonstrated that daptomycin was stable and compatible when admixed with commonly administered. Following administration of a single 4 mgkg iv dose, the mean total clearance of daptomycin was reduced approximately 35% and.
There is an antibiotic imipramine something like that its combination with some other antibiotc cant remember the name so the question is can we piggyback that antibiotic with d5w. You can publish your book online for free in a few minutes. Cubicin is supplied in singleuse vials, each containing 500 mg daptomycin as a sterile, lyophilized powder. Daptomycin is poorly absorbed orally and should only be administered intravenously. Stability and compatibility of reconstituted ertapenem with commonly. Intravenous injection introduced directly into a vein or a freely flowing iv line. Side effects of cubicin daptomycin injection, warnings, uses. Daptomycin is an antibiotic that is used to treat bacterial infections of the skin and underlying tissues, and infections that have entered the bloodstream daptomycin is used for complicated infections, including mrsa or super bug infections. Daptomycin is used in the treatment of complicated skin and soft. Daptomycin injection fda prescribing information, side. In the core registry, the median duration of iv daptomycin therapy for csssis was days range 2148 days compared to the basecase number of 6. Daptomycin appears to be a promising agent for use in peritoneal dialysisassociated peritonitis, producing bacterial kill to a greater extent and at a higher rate than cefazolin or vancomycin in pdf. Because only limited data are available on the compatibility of daptomycin for injection with other iv substances, additives and other medications should not be added to daptomycin for injection singledose vials or infusion bags, or infused simultaneously with daptomycin for injection through the same iv line.
Intravenous compatibility chartcisatracurium nimbex dexmedetomidine precedex dobutamineacyclovir acyclovir. Selected from data included with permission and ed by first databank, inc. Daptomycin is a lipopeptide antibiotic used in the treatment of systemic and lifethreatening infections caused by grampositive organisms. J0878 is a valid 2020 hcpcs code for injection, daptomycin, 1 mg or just daptomycin injection for short, used in medical care. Daptomycin appears promising as a safe and efficacious drug for the treatment of pediatric diseases caused by grampositive pathogens. See what others have said about daptomycin, including the effectiveness, ease of use and side effects. Because only limited data are available on the compatibility of daptomycin for injectionwith other iv substances, additives and other medications should not be added to daptomycin for injection singledose vials or infusion bags, or infused simultaneously with daptomycin for injection through the same iv line. Daptomycin may also be used for purposes not listed in this medication guide. Filter material impact on solution appearancea impact on potencyb covidien monoject 5 m m305 stainless steel no no bd nokor 5 m 305200 acrylic copolymernylon no no thermo scientific nalgene 0. The stability of ertapenem sodium in various commonly used i. The cubicin rf formulation of daptomycin is compatible with 0. Intravenous iv dilution medication dosing database dose guidelines for iv titratable drugs and other agents, medical dosage calculations. Daptomycin is recognized as an important agent in opat practice due to its spectrum of activity and ease of administration.
Ten vials of daptomycin lot cdc079 were reconstituted with 10 ml of 0. The 2 formulations have differences regarding storage. This product is available in the following dosage forms. Cubicin daptomycin dosing, indications, interactions. Use of daptomycin for the treatment of methicillinresistant coagulasenegative staphylococcal ventriculitis. Daptomycin is a novel antibiotic first in the class of drugs known as lipopeptide. Costeffectiveness analysis of linezolid, daptomycin, and.
Compatibility of daptomycin with commercially available. Vancomycin is the standard firstline treatment for methicillinresistant staphylococcus aureus bacteremia. Read 29 kindle store comprehensive iv compatibility chart foldout arms you with compatibility. Safety concerns with daptomycin cubicin include musclerelated adverse events. If same iv line used for sequential infusion of other drugs, flush the line before and after infusion of this drug with a compatible iv solution. Daptomycin is associated with a low to modest rate of serum enzyme elevations during therapy, but is a very rare cause of clinically apparent liver injury. Renal dose adjustment guidelines for antimicrobials. Covering the relevant world literature through 2003, this book picks up. Drugs az pill identifier supplements symptom checker diseases dictionary media slideshows images quizzes. Daptomycin is an intravenously administered, broad spectrum antibiotic used to treat complex skin and tissue infections, endocarditis and bacteremia. The product catalog provides you with a full listing of tevas brand and generic product lines. By continuing to browse this site you are agreeing to our use of cookies. Resistant coagulasenegative staphylococcal ventriculitis.
Objectives daptomycin is a cyclic lipopeptide with selective action against drugresistant grampositive bacteria. Cubicin and cubicin rf have not been studied in patients with prosthetic valve endocarditis. Daptomycin is a prescription medication used to treat serious skin and blood infections caused by staphylococcus aureus a type of bacteria. Although daptomycin resistance has been documented, it remains uncommon. Its distinct mechanism of action makes it useful in treating infections caused by multiple drugresistant bacteria.
The stability of daptomycin solutions in different containers while stored at different temperatures was assessed. Cubicin 350 mg powder for solution for injection or. Cvvhd removes solutes including drugs via diffusion. Antibiotic drugs, daptomycin, ertapenem and fidaxomicin. Daptomycin must be given slowly, and the iv infusion can take 2 to 30 minutes to complete.
This medicine is to be given only by or under the direct supervision of your doctor. Formulation differences cubicin daptomycin for injection. Compatibility was defined for the filtered samples as no visible difference in the appearance versus the unfiltered control and no more than a 5% decrease in potency from the unfiltered control. Cases of interference between daptomycin and a reagent used in. Because only limited data are available on the compatibility of cubicin with other iv. The system learns from interaction with users and will be able to answer more sophisticated questions over time. Mrsa stands for methicillinresistant staphylococcus aureus. Cubicin daptomycin dose, indications, adverse effects. Daptomycin belongs to a group of drugs called lipopeptide antibiotics, which work by binding to bacteria and killing them. Observational studies clinical experience of daptomycin for grampositive infections skin and soft tissue infections, bacteremia, endocarditis, and bone and. Stability of daptomycin reconstituted vials and infusion. Incompatibilities are based on meeting any of the following criteria. Intravenous iv preparation and infusion guidelines globalrph. Because only limited data are available regarding compatibility with other iv substances, additives or other medications should not be added to daptomycin vials or infusion bags.
When a patient is initiated on crrt, antimicrobial therapy often requires adjustment to ensure adequate drug concentrations are achieved. The length of your treatment depends on the type of infection being treated and your response to daptomycin treatment. It is a cyclic lipopeptide derived from streptomyces roseosporus. Find patient medical information for daptomycin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
I had a question about compatibility of iv antibiotics. Because only limited data are available on the compatibility of cubicin rf with other iv substances, additives and other medications should not be added to cubicin rf singledose vials or infusion bags, or infused simultaneously with cubicin rf through the same iv line. Intravenous compatibility chart free html5 flip book. When giving this medicine to a child or teenager, the infusion is. It is not known whether this drug passes into breast milk. Cubicin daptomycin for injection for intravenous use fda. The catalog displays all strengths and sizes along with the description, imprint code, ndc and photo for each product. Our cubicin daptomycin side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Daptomycin belongs to the class of medicines known as antibiotics. Do not add additives or other drugs to daptomycin solutions. Daptomycin injection comes as a powder to be added to fluid and injected into a vein by a doctor or nurse. What are the generic drug sources for daptomycin and what is the scope of patent protection daptomycin is the generic ingredient in three branded drugs marketed by cubist pharms llc, accord hlthcare, be pharms, dr reddys, fresenius kabi usa, hospira inc, jiangsu hengrui med, mylan labs ltd, sagent pharms inc, teva pharms usa, and xellia pharms aps, and is included in fourteen. Daptomycin side effects, dosage, interactions drugs.
Daptomycin is a cyclic lipopeptide compound with amino acids and which comprises of a core with hydrophilic properties and also a tail which has high lipophilicity. To date however, there have been no headtohead randomized trials comparing the. To get the free app, enter your mobile phone number. Pdf use of daptomycin for the treatment of methicillin. On the whole, daptomycin cubicin has not been shown to provide any clinical advantage over other antimicrobial drugs in the treatment of s. Cubicin and cubicin rf are not recommended in pediatric patients younger than 1 year of age due to the risk of potential effects on muscular, neuromuscular, andor nervous systems either peripheral andor central observed in neonatal dogs. Watson is in medical residency and can answer many drug information questions. Daptomycin compatibility in peritoneal dialysis solutions. This medication comes in an injectable form to be given directly into the vein iv by a healthcare professional.
Intramuscular injection is prohibited as it causes direct toxicity. Calcium chloride ampicillin ampicillin yes calcium. One ml provides 50 mg of daptomycin after reconstitution with 7 ml of sodium chloride 9 mgml 0. Compatibility with the coinfusion solutions was monitored for up to eight hours at room temperature. However, recent consensus guidelines recommend that clinicians consider using alternative agents such as daptomycin when the vancomycin minimum inhibitory concentration is greater than 1 ugml. This ed material has been downloaded from a licensed data provider and is not for distribution, except. Dailymed daptomycin injection, powder, lyophilized, for. Daptomycin intravenous route description and brand names. The basecase results were sensitive to these data and demonstrated the importance of using observational studies in da modeling. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a.
Compatibility of daptomycin with selected syringe filters brand pore size part no. However, this medicine will not work for colds, flu, or other virus infections. Trissel, fashp, 2010, american society of healthsystem pharmacists. Drugs administered other than oral method, chemotherapy drugs.
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